Three goals inside four minutes in the first half swept Wigan into their first FA Cup semi-final at the expense of a shocked Everton.
Luis Suarez scored a hat-trick as Liverpool thrashed Wigan and boosted their hopes of European qualification.
Two goals by Arouna Kone lifted Wigan Athletic out of the bottom three and increased 10-man Reading's relegation fears at the Madejski Stadium.
Frank Lampard moved to within four goals of becoming Chelsea's all-time leading scorer to help his side record back-to-back Premier League home wins for the first time since October.
Shaun Maloney's 90th-minute goal rescued a draw for relegation-threatened Wigan against fellow strugglers Southampton.
Wigan fought back from two goals down to rescue a point at Stoke and move out of the Premier League relegation zone.
Wigan survived a stern test from non-league Macclesfield to reach the fifth-round of the FA Cup for only the second time in their history.
Steven Fletcher scored twice as Sunderland came from behind to win a five-goal thriller and send Wigan Athletic into the bottom three.
Franco Di Santo's first Premier League goal in three months earned Wigan Athletic a deserved point at Fulham.
Javier Hernandez and Robin van Persie scored twice as Premier League leaders Manchester United coasted past Wigan to preserve their seven-point lead.
Wigan Athletic moved out of the Premier League relegation zone and above Aston Villa with an emphatic victory over their struggling hosts.
Everton stretched their unbeaten run to seven Premier League games as goals from Leon Osman and Phil Jagielka gave them victory over Wigan.
Mikel Arteta's penalty secured a third consecutive Premier League victory for Arsenal for the first time since March.
Wes Hoolahan's fine individual display helped Norwich beat Wigan 2-1 to extend their unbeaten league run to 10 games.
Queens Park Rangers set a new record for the longest winless start to a Premier League season after James McCarthy rescued Wigan.
Demba Ba strikes twice and Gael Bigirimana hits a stunning third as Newcastle beat 10-man Wigan to end a run of four defeats.
Second-half strikes from Mario Balotelli and James Milner help Manchester City recover from a slow start to beat Wigan 2-0.
Jordi Gomez scored a stoppage-time winner to complete a memorable hat-trick and earn Wigan a dramatic victory over Reading at the DW Stadium.
Luis Suarez inspired Liverpool to a dominant second-half display which saw off bogey-team Wigan at Anfield.
West Brom maintained their excellent start under manager Steve Clarke with a deserved win at Wigan, keeping them fifth in the Premier League.