Southampton secured their first league victory of the season thanks to four second-half goals against Aston Villa.
Arsenal produced a superb first-half display of attacking football to sweep bottom-placed club Southampton aside.
Hat-trick hero Robin van Persie scored two late goals to prevent newly-promoted Southampton ruining Sir Alex Ferguson’s 1,000th league match in charge as Manchester United manager.
Wigan claimed their first win of the season in a sparsely-filled St Mary’s as Southampton’s seven-year wait for a top flight home game ended poorly.
Samir Nasri saved Manchester City’s blushes as the Frenchman scored a late winner to beat a battling Southampton in a dramatic game at the Etihad.